Thymidine Totally Explained

Everything about Thymidine totally explained

|Section2= |Section3= }} Thymidine (more precisely called deoxythymidine; can also be labelled deoxyribosylthymine, and thymine deoxyriboside) is a chemical compound, more precisely a pyrimidine deoxynucleoside. Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it's used to synchronize the cells in S phase.

Structure and properties

In its composition, deoxythymidine is deoxyribose (a pentose sugar) joined to the pyrimidine base thymine.
   Deoxythymidine can be phosphorylated with one, two or three phosphoric acid groups, creating respectively dTMP, dTDP or dTTP ((deoxy)thymidine mono- di- or triphosphate).
   It exists in solid form as small white crystals or white crystalline powder, has a molecular weight of 242.229 u, and has a melting point of 185 °C. The stability of deoxythymidine under standard temperature and pressure (STP) is very high.
   Deoxythymidine is non-toxic and as part of one of the four nucleotides in DNA it's a naturally occurring compound that exists in all living organisms and DNA viruses. RNA has uridine (uracil joined to ribose) instead. Uracil is chemically very similar to thymine, the latter being 5-methyluracil. Since thymine nucleotides are precursors of DNA, not RNA, the prefix "deoxy" is often left out, for example, deoxythymidine is often just called thymidine.

Modified analogs of thymidine

Iododeoxyuridine is a radiosensitizer and increases the amount of DNA damage received from ionizing radiation. Azidothymidine (AZT) - used in the treatment of HIV infection. AZT inhibits the process of reverse transcription, a critical step in the viral life cycle. Tritiated thymidine is commonly used in cell proliferation assays. The thymidine is incorporated into dividing cells and the level of this incorporation, measured using a liquid scintillation counter, is proportional to the amount of cell proliferation. Bromodeoxyuridine (BrdU) is another thymidine analog that's often used for the detection of proliferating cells in living tissues.

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